Scope and limitations of 1,3,5-hexatriene derivatives in regioselective cobalt-catalyzed reactions
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Updated: May 11, 2026

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
Published on: August 12, 2019
Anastasia Schmidt1, Gerhard Hilt
1Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany.
Abstract:
Applications of 1,3,5-hexatriene derivatives in atom-economic cobalt-catalyzed transformations, such as the Diels-Alder reaction with alkynes, the 1,4-hydrovinylation reaction with terminal alkenes, and the 1,4-hydrohexatrienylation reaction, are investigated. In all cases, regioselective transformations were found to generate cyclic derivatives such as stilbenes or acyclic products with a high control of the double bond geometry in the skipped trienes derived from the 1,4-hydrovinylation process or the tetraenes generated in the so far unprecedented 1,4-hydrohexatrienylation reaction.
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