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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Aquagenic urticaria in twins
1Cutaneous Allergy Department, St John's Institute of Dermatology, Guy's & St Thomas' NHS Foundation Trust, Westminster Bridge Road, SE1 7EH, London, UK. annekekai@doctors.org.uk.
The World Allergy Organization Journal
|May 14, 2013
Summary
This study reports the first case of aquagenic urticaria in identical twins. The findings suggest a potential genetic link to this rare water-induced skin condition.
Area of Science:
- Dermatology
- Genetics
Background:
- Aquagenic urticaria is a rare condition causing hives upon water contact.
- Its exact cause remains unknown, with most cases being sporadic.
Observation:
- An 18-year-old pair of identical twins presented with a 3-year history of aquagenic urticaria.
- This marks the first documented instance of aquagenic urticaria in monozygotic twins.
Findings:
- The occurrence in twins strengthens the hypothesis of a genetic predisposition.
- No specific genetic mutation has been identified to date.
Implications:
- Further research into the genetic basis of aquagenic urticaria is warranted.
- Understanding genetic factors may lead to novel diagnostic or therapeutic approaches.
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