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Anti-inflammatory effects of clarithromycin in ventilator-induced lung injury

Laura Amado-Rodríguez, Adrián González-López, Inés López-Alonso

    Respiratory Research
    |May 14, 2013
    PubMed
    Abstract

    Insights

    Clarithromycin treatment reduced lung injury and neutrophil infiltration in mice undergoing mechanical ventilation. This macrolide antibiotic shows promise for patients with acute lung injury.

    Area of Science:

    • Pulmonary Medicine
    • Pharmacology
    • Immunology

    Background:

    • Mechanical ventilation can induce lung injury through inflammation.
    • Macrolides possess immunomodulatory properties and offer benefits in ventilated patients.
    • This study investigates macrolides' potential to mitigate ventilator-induced lung injury (VILI).

    Purpose of the Study:

    • To evaluate the efficacy of macrolides in reducing ventilator-induced lung injury.
    • To compare clarithromycin and levofloxacin effects on lung inflammation and injury markers.

    Main Methods:

    • Adult mice received vehicle, clarithromycin, or levofloxacin.
    • Mice were subjected to low or high-pressure mechanical ventilation.
    • Lung injury, neutrophil infiltration, inflammatory mediators, adhesion molecules, and proteases were assessed.

    Main Results:

    • Clarithromycin significantly reduced lung injury score and neutrophils post-high-pressure ventilation.
    • Both clarithromycin and levofloxacin inhibited NFκB activation.
    • Clarithromycin prevented the increase in E-selectin levels during injurious ventilation.

    Conclusions:

    • Clarithromycin ameliorates ventilator-induced lung injury by decreasing neutrophil recruitment.
    • These findings support the use of macrolides in patients with acute lung injury requiring mechanical ventilation.

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