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Related Experiment Video

Updated: May 11, 2026

Evaluating the Function of the Foot Core System in the Elderly

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

[Graves' dermopathy on the big toe].

E Couderc¹, V Cante, O Renaud

¹Service de dermatologie, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers cedex, France. elodie.couderc@sfr.fr

Annales De Dermatologie Et De Venereologie

|May 14, 2013

Summary

This summary is machine-generated.

Localized myxedema, a rare skin condition in Graves' disease patients, typically affects the shins. This case highlights an unusual presentation of myxedema on the big toes, successfully treated with intralesional steroids.

Related Experiment Videos

Last Updated: May 11, 2026

Evaluating the Function of the Foot Core System in the Elderly

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

Area of Science:

Endocrinology
Dermatology
Autoimmune diseases

Background:

Localized myxedema is a rare skin manifestation associated with Graves' disease.
The pretibial region is the most common site, but atypical locations can occur.

Observation:

A 44-year-old male with a 7-year history of Graves' disease presented with bilateral ophthalmopathy and myxedema affecting the big toes.
This represents an unusual, non-pretibial localization of localized myxedema.

Findings:

The myxedema of the big toes showed a positive response to intralesional steroid injections.
The physiopathology involves fibroblast activation and glycosaminoglycan deposition, potentially triggered by TSH receptor antibodies or inflammation.

Implications:

Atypical localization may be linked to the Koebner phenomenon.
Standard Graves' disease treatment often doesn't resolve cutaneous manifestations; topical corticosteroids are effective for recent lesions.