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[BCG osteitis. A case report].

D Friebel1, R Fischer, E Rupprecht

  • 1Klinik für Kinderheilkunde, Medizinischen Akademie Carl Gustav Carus Dresden.

Kinderarztliche Praxis
|April 1, 1990
PubMed
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BCG-Ostitis, a rare bone infection, can occur after Bacillus Calmette-Guérin vaccination in infants. Prompt tuberculostatic therapy led to complete healing in an 8-month-old girl, confirming vaccination

Area of Science:

  • Pediatric Orthopedics
  • Infectious Diseases
  • Vaccinology

Background:

  • The Bacillus Calmette-Guérin (BCG) vaccine is widely used for tuberculosis prevention.
  • BCG-Ostitis, a rare complication, can manifest as bone infection following vaccination.
  • Early diagnosis and treatment are crucial for favorable outcomes in pediatric bone infections.

Observation:

  • An 8-month-old female infant presented with symptoms suggestive of bone infection.
  • Radiological, histological, and immunohistochemical examinations confirmed BCG-Ostitis in the proximal left humerus.
  • The clinical presentation and diagnostic findings were consistent with a BCG vaccine-related osteomyelitis.

Findings:

  • The affected bone was the head of the left humerus.

Related Experiment Videos

  • Diagnostic methods included radiography, histology, and immunohistochemistry, all showing characteristic changes.
  • Tuberculostatic therapy was initiated for the patient.

    • Implications:

    • This case highlights the importance of recognizing BCG-Ostitis as a potential, albeit rare, complication of BCG vaccination.
    • Effective treatment with tuberculostatic agents can lead to complete resolution of BCG-Ostitis.
    • The study reinforces the overall safety and efficacy of BCG vaccination despite rare adverse events.