Related Experiment Video
Updated: Aug 9, 2026

Burn Injury-Induced Pain and Depression-Like Behavior in Mice
Published on: September 29, 2021
[The effect of combined methods of detoxication on the development of inflammatory reactions in severe burns]
Abstract:
The development of inflammatory reaction in 106 patients with severe and extremely severe burns in combined use in the complex treatment of extracorporeal hemosorption, enterosorption, applicative sorption by the powdery PMS-Zn sorbent, passive immunotherapy was studied. The modulative effect of the methods of general and local sorptive detoxication on the development of inflammatory reaction of the area of thermal trauma with reduction of damaging effect of proteolytic enzymes and formation of cellular reaction directed at protection from microorganisms and beginning of the proliferative stage of reparative regeneration is shown. Lethality in severe burns was 17.7%, in extremely severe--50.8%.
Related Concept Videos
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Prevention of Further Absorption of Poison
Drug Toxicity: Allergic Reactions
Pharmaceutical Poisoning: Treatment Strategies
Acute Inflammation III: Local and Systemic Effects

