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Leptomeningeal metastasis of an intradural malignant peripheral nerve sheath tumor

Andreas M Stark1, H Maximilian Mehdorn

  • 1Klinik für Neurochirurgie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 2, Haus 41, 24105 Kiel, Germany. starka@nch.uni-kiel.de

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|May 14, 2013
PubMed

Insights

Malignant peripheral nerve sheath tumors (MPNST) can spread to the brain and spine. This case report details the first known instance of leptomeningeal metastasis from an intradural MPNST.

Area of Science:

  • Neuro-oncology
  • Oncopathology

Background:

  • Malignant peripheral nerve sheath tumors (MPNST) are rare and aggressive neoplasms.
  • Intradural MPNST are uncommon, and their metastatic potential to the central nervous system is poorly understood.

Observation:

  • A 56-year-old woman presented with leptomeningeal and brain metastases 19 months after diagnosis of a primary intradural MPNST.
  • The patient had a history of spinal irradiation for non-Hodgkin's lymphoma 15 years prior.
  • No stigmata of neurofibromatosis type 1 were present.

Findings:

  • This represents the first reported case of leptomeningeal metastasis of an MPNST to both the spine and intracranial space.
  • The findings suggest that intradural MPNST, particularly post-radiation, can metastasize leptomeningeally.

Implications:

  • This case expands the known metastatic patterns of MPNST.
  • Highlights the importance of considering leptomeningeal spread in patients with intradural MPNST, especially those with a history of radiation therapy.
  • May influence future surveillance and treatment strategies for MPNST patients.
Keywords:
LeptomeningealMPNSTMalignant peripheral nerve sheath tumorMetastases

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