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Related Experiment Video

Updated: May 11, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

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Transthyretin and the human placenta.

K A Landers¹, R H Mortimer, K Richard

¹Conjoint Endocrine Laboratory, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, 4006 Brisbane, Australia. Kelly.Landers@qimr.edu.au

|May 14, 2013

Summary

Transthyretin (TTR) is vital for transporting thyroid hormones and retinol. Recent findings highlight TTR

Area of Science:

Biochemistry
Endocrinology
Reproductive Biology

Background:

Transthyretin (TTR) is primarily known as a hepatic protein carrier for thyroid hormones and retinol.
Emerging research indicates TTR's involvement in cerebrospinal fluid and potential roles in neurological functions.
TTR amyloidosis encompasses several serious diseases, including senile systemic amyloidosis and familial amyloid polyneuropathies.

Purpose of the Study:

To review the diverse functions of transthyretin (TTR).
To explore recent findings on TTR synthesis, secretion, and uptake in the human placenta.
To elucidate TTR's role in maternal-fetal thyroid hormone delivery.

Main Methods:

Literature review of existing studies on transthyretin (TTR).

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Analysis of recent research on placental TTR expression and function.

Synthesis of findings regarding TTR's role in fetal development.

Main Results:

Transthyretin (TTR) plays a significant role in transporting thyroid hormones into the brain.
TTR amyloidosis is linked to severe systemic and neurological diseases.
Human placenta synthesizes, secretes, and uptakes TTR, indicating a crucial role in fetal development.

Conclusions:

Transthyretin (TTR) has multifaceted functions beyond its traditional carrier roles.
Placental TTR is essential for delivering maternal thyroid hormones to the developing fetus.
Further research into TTR's placental functions may offer insights into pregnancy health and fetal development.