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Updated: May 11, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Rehabilitation after trauma; does age matter?
Bellal Joseph1, Viraj Pandit, Hassan Aziz
1Division of Trauma, Critical Care, and Acute Care Surgery, Department of Surgery, University of Arizona, Tucson, Arizona 85727, USA. bjoseph@surgery.arizona.edu
Functional recovery after trauma is variable. Hospital length of stay and head injury severity negatively impact functional improvement in trauma patients undergoing rehabilitation.
Area of Science:
- Trauma Rehabilitation
- Functional Recovery
- Predictive Factors in Medicine
Background:
- Predicting patient recovery after trauma and inpatient rehabilitation presents challenges due to significant variability.
- Identifying key factors that influence functional improvement is crucial for optimizing patient outcomes.
Purpose of the Study:
- To identify hospital admission factors that predict functional improvement in trauma patients during inpatient rehabilitation.
- To analyze the relationship between various patient characteristics and their functional gains post-trauma.
Main Methods:
- Retrospective cohort analysis of a prospectively collected database of trauma patients (n=160).
- Functional Independence Measure (FIM) scores were collected at hospital discharge and rehabilitation discharge.
- Multiple linear regression analysis was used to identify predictors of delta FIM (change in FIM scores).
Main Results:
- Hospital length of stay and higher head Abbreviated Injury Score (AIS) on admission were negative predictors of functional improvement (delta FIM).
- Factors such as age, gender, Glasgow Coma Scale, Injury Severity Score, systolic blood pressure, and ICU length of stay did not predict functional outcome.
- Mean change in FIM scores was 39.4 ± 13, with 29 patients being totally dependent and 131 partially dependent at rehabilitation admission.
Conclusions:
- Age was not an independent predictor of functional outcome in this trauma patient cohort.
- The severity of head injury significantly and negatively impacts overall functional improvement following trauma and rehabilitation.
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