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Utilizing Thermal Shift Assay to Probe Substrate Binding to Selenoprotein O
Published on: August 9, 2024
A bioassay-driven discovery of an unexpected selenophene and its cytotoxicity
René Csuk1, Bianka Siewert, Jana Wiemann
1Martin-Luther-Universität Halle-Wittenberg, Organische Chemie, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. rene.csuk@chemie.uni-halle.de
Bioorganic & Medicinal Chemistry Letters
|May 14, 2013
Abstract:
During the reaction of methyl 3β-acetoxy-glycyrrhetinate (1) with SeO2 significant amounts of a cytotoxic hitherto unprecedented triterpenoic selenophene 3 are formed. This compound stops cell proliferation and acts by apoptosis.
