Related Experiment Video
Updated: May 11, 2026
14:23
Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
CD147 in regulatory T cells
Johannes Landskron1, Kjetil Taskén
1Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, P.O. Box 1125 Blindern, N-0318 Oslo, Norway.
Cellular Immunology
|May 14, 2013
Summary
CD147, a membrane receptor, is highly expressed in regulatory T cells and linked to their suppressive function. This suggests CD147 could serve as a valuable marker for identifying activated regulatory T cells in the immune system.
Area of Science:
- Immunology
- Cell Biology
- Molecular Medicine
Background:
- CD147, also known as EMMPRIN, is an immunoglobulin superfamily member expressed on various cells, including immune cells.
- In T cells, CD147 acts as a receptor for soluble cyclophilins, influencing cellular processes like chemotaxis.
- Recent findings highlight high CD147 expression and its association with suppressive functions in regulatory T cells.
Purpose of the Study:
- To explore the potential of CD147 as a biomarker.
- To investigate the role of CD147 in regulatory T cell function.
Main Methods:
- The study discusses the expression patterns of CD147.
- It reviews the functional implications of CD147 in T cells, particularly regulatory T cells.
- The research synthesizes existing data to propose CD147 as a marker.
Main Results:
- CD147 is expressed at high levels on regulatory T cells.
- High CD147 expression correlates with the suppressive capacity of regulatory T cells.
Conclusions:
- CD147 shows promise as a reliable marker for activated regulatory T cells.
- Identifying activated regulatory T cells via CD147 could advance immunological research and therapeutic strategies.
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