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Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals
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Application of in vitro biopharmaceutical methods in development of immediate release oral dosage forms intended for

Hannah K Batchelor1, Richard Kendall, Sabine Desset-Brethes

  • 1Pharmacy, Pharmacology and Therapeutics Section, University of Birmingham, Birmingham, UK.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|May 14, 2013
PubMed

Keywords:
(United States) Food and Drug AdministrationAbsorptionBCSBioavailabilityBiopharmaceuticsBiopharmaceutics classification systemDissolutionEMAEuropean Medicines AgencyFDAFaSSIFFasted state simulated intestinal fluidFeSSIFFed state simulated intestinal fluidGIGastrointestinalIVIVRIn vitro in vivo relationshipMADMaximum absorbable doseP-GlycoproteinP-gpPBPKPKPaediatricPermeabilityPharmacokineticPhysiologically based pharmacokineticSGFSimulated gastric fluidSolubilityUSPUnited States pharmacopoeia

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