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Updated: May 11, 2026

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings
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Wound 'dechronification' with negatively-charged polystyrene microspheres: a double-blind RCT.

Y Shoham1, L Kogan, J Weiss

  • 1Plastic Surgery Department, Soroka University Medical Center, Be'er Sheva, Israel. yshoham@bgu.ac.il

Journal of Wound Care
|May 14, 2013
PubMed
Summary
This summary is machine-generated.

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Negatively-charged polystyrene microspheres (NCM) significantly improved granulation tissue formation and reduced wound size in hard-to-heal wounds compared to saline soaks. This treatment effectively promotes healing in chronic wounds.

Area of Science:

  • Wound healing research
  • Biomaterials in medicine
  • Regenerative medicine

Background:

  • Hard-to-heal wounds pose a significant clinical challenge.
  • Chronic wounds often exhibit delayed healing and require advanced treatment modalities.
  • Existing treatments may not always be effective for complex wound etiologies.

Purpose of the Study:

  • To evaluate the efficacy and safety of negatively-charged polystyrene microspheres (NCM) versus saline controls.
  • To assess NCM's impact on granulation tissue formation in chronic wounds.
  • To compare wound size reduction in NCM-treated versus control groups.

Main Methods:

  • Randomized controlled trial involving patients with hard-to-heal wounds.
  • NCM (PolyHeal) or saline soaks applied twice daily for 4 weeks.

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Published on: March 25, 2020

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Last Updated: May 11, 2026

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Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
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Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

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  • Bi-weekly monitoring for 8 weeks post-treatment, with a 2-year follow-up.

    • Main Results:

    • 47% of patients in the NCM group achieved >75% granulation tissue coverage vs. 15% in controls (p=0.01).
    • Mean wound surface area reduction was 39.0% with NCM vs. 14.9% with controls (p=0.02).
    • Positive trends observed in venous insufficiency and post-trauma wound subgroups.

    Conclusions:

    • NCM treatment significantly enhances healthy granulation tissue formation.
    • NCM effectively reduces wound size in hard-to-heal and chronic wounds.
    • NCM 'kick-starts' the healing process and 'dechronifies' chronic wounds.