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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

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Published on: November 7, 2025

Defining high-risk prostate cancer.

Hanan Goldberg¹, Jack Baniel, Ofer Yossepowitch

¹The Institute of Urology, Rabin Medical Center, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Current Opinion in Urology

|May 14, 2013

Summary

This summary is machine-generated.

Defining high-risk prostate cancer remains challenging due to inconsistent criteria. Patients with localized high-risk prostate cancer may still benefit from curative local therapy.

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Area of Science:

Oncology
Urology

Background:

High-risk prostate cancer is a lethal disease necessitating prompt diagnosis and treatment.
Current definitions for high-risk prostate cancer lack standardization, complicating patient stratification.

Purpose of the Study:

To review contemporary definitions of high-risk prostate cancer.
To evaluate the clinical utility of these definitions in patient management.

Main Methods:

Literature review of current definitions and clinical studies.
Analysis of pathological features, treatment outcomes, and predictive factors.

Main Results:

High-risk prostate cancer is a heterogeneous group with variable outcomes.
Some patients have localized disease curable with surgery, while others have systemic disease.
Current definitions lack sufficient sensitivity and specificity.

Conclusions:

Standardized criteria for high-risk prostate cancer are needed.
Patients with clinically localized high-risk prostate cancer should not be excluded from curative local definitive therapy.