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Updated: May 11, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Coumarin chalcone fibrates: a new structural class of lipid lowering agents
Koneni V Sashidhara1, Gopala Reddy Palnati, Ravi Sonkar
1Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India. sashidhar123@gmail.com
Abstract:
In our continuing search for safe and efficacious antidyslipidemic agents, structurally interesting coumarin-chalcone fibrates were synthesized and evaluated in triton WR-1339 induced hyperlipidemic rats. The most active compound 41 decreased the total cholesterol (TC), phospholipids (PL) and triglycerides (TG), of hyperlipidemic rats by 26, 24, and 25% respectively. In addition, the compound 41 significantly reversed the levels of VLDL, LDL HDL and also increased the LPL activity. Altogether, our data suggests that these novel hybrids would be a potential new class of therapeutic agents against dyslipidemia.
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