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Related Experiment Video

Updated: May 11, 2026

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

Published on: April 28, 2022

Chlorhexidine: uses and adverse reactions.

Dianne L Silvestri¹, Melissa McEnery-Stonelake

¹Division of Dermatology, University of Massachusetts Medical School, Worcester, MA 01605, USA. dianne.silvestri@umassmemorial.org

Dermatitis : Contact, Atopic, Occupational, Drug

|May 14, 2013

Summary

Widespread use of chlorhexidine, an antiseptic and preservative, is linked to increasing adverse reactions. Physicians must recognize potential sources and symptoms of chlorhexidine sensitization, ranging from dermatitis to anaphylaxis.

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Last Updated: May 11, 2026

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

Published on: April 28, 2022

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

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Published on: November 1, 2013

Area of Science:

Medical Microbiology
Dermatology
Allergy and Immunology

Background:

Chlorhexidine is a widely used antiseptic for preventing infections and in oral hygiene.
Its application extends to personal care products, increasing general population exposure.
Reports of adverse reactions to chlorhexidine are on the rise.

Purpose of the Study:

To highlight the increasing incidence of adverse reactions to chlorhexidine.
To inform healthcare professionals about the spectrum of chlorhexidine-induced complications.
To emphasize the importance of recognizing chlorhexidine sensitization.

Main Methods:

Review of clinical reports and scientific literature on chlorhexidine adverse reactions.
Analysis of case studies detailing irritant contact dermatitis and anaphylaxis.
Correlation of exposure sources with sensitization and reaction severity.

Main Results:

Adverse reactions to chlorhexidine encompass a range from mild irritant contact dermatitis to severe anaphylaxis.
Allergic contact dermatitis can be a precursor to anaphylactic reactions.
Increased use correlates with a higher frequency of reported hypersensitivity.

Conclusions:

Physicians need heightened awareness of diverse chlorhexidine exposure routes.
Early recognition of chlorhexidine sensitization is crucial for preventing severe outcomes.
Prompt diagnosis and management are essential for patients experiencing chlorhexidine-related adverse events.