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Effect of lifestyle modifications on diastolic functions and aortic stiffness in prehypertensive subjects: a

Şeref Alpsoy1, Mustafa Oran, Birol Topcu

  • 1Departments of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdağ-Turkey. serefalpsoy@hotmail.com.

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|May 14, 2013
PubMed

Insights

Therapeutic lifestyle modifications significantly improved cardiac diastolic function and reduced aortic stiffness in prehypertensive individuals. These changes suggest a potential benefit for cardiovascular health in this at-risk population.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Echocardiography

Background:

  • Prehypertension is a significant risk factor for major cardiovascular events.
  • Early identification and intervention are crucial for cardiovascular risk reduction.

Purpose of the Study:

  • To assess the impact of therapeutic lifestyle modifications (LSMs) on cardiac diastolic function.
  • To evaluate the effect of LSMs on aortic stiffness in individuals with prehypertension.

Main Methods:

  • Prospective cohort study involving 61 prehypertensive adults.
  • LSMs included weight loss (≥5 kg for BMI ≥25 kg/m²) and moderate physical activity (≥180 min/week).
  • Evaluated left ventricular diastolic function and aortic stiffness using echocardiography and tissue Doppler imaging (TDI) at baseline and 6 months.

Main Results:

  • Significant improvements in transmitral flow velocities (E, E/A) and TDI parameters (septal E, septal S, lateral E, septal E/A, lateral E/A) were observed.
  • The beta stiffness index decreased significantly (p<0.001).
  • Aortic compliance and aortic strain increased significantly (p<0.001) after LSMs.

Conclusions:

  • Therapeutic lifestyle modifications effectively enhance conventional and TDI echocardiographic parameters in prehypertensive subjects.
  • LSMs lead to significant improvements in aortic stiffness measurements.
  • These findings highlight the role of LSMs in mitigating cardiovascular risk in prehypertension.
Abstract

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