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Published on: January 28, 2020
Inflammatory markers are elevated in Eisenmenger syndrome.
Sivasubramanian Ramakrishnan1, Bharat Bhooshan Kukreti, Lakshmy Ramakrishnan
1Department of Cardiology, All India Institute of Medical Sciences (AIIMS), New Delhi, 110 029, India, ramaaiims@gmail.com.
Pediatric Cardiology
|May 14, 2013
Summary
Systemic inflammation markers, high-sensitivity C-reactive protein (hs-CRP) and interferon-gamma (IFN-γ), are elevated in Eisenmenger syndrome (ES). Elevated hs-CRP was linked to older age and reduced exercise capacity in ES patients.
Area of Science:
- Cardiology
- Immunology
- Pulmonary Medicine
Background:
- Inflammation is a potential factor in Eisenmenger syndrome (ES) progression.
- Systemic inflammation markers in ES have not been thoroughly investigated.
Purpose of the Study:
- To systematically study systemic inflammation markers in ES patients.
- To correlate these markers with clinical and hemodynamic variables and patient outcomes.
Main Methods:
- Measured hs-CRP, IL-2, IL-6, and IFN-γ in 42 ES patients and 22 healthy controls.
- Correlated inflammatory marker levels with baseline parameters and clinical outcomes over a mean follow-up of 16.3 months.
Main Results:
- ES patients exhibited significantly elevated hs-CRP and IFN-γ compared to controls.
- Higher hs-CRP levels correlated with older age and shorter 6-minute walk distance.
- Inflammatory marker levels did not predict clinical outcomes like death or hospitalization.
Conclusions:
- hs-CRP and IFN-γ are significantly elevated in Eisenmenger syndrome.
- Elevated hs-CRP is associated with specific demographic and functional characteristics in ES.
- Current inflammatory markers studied do not predict clinical events in ES.
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