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Cardiac structure and functions in patients with asymptomatic primary hyperparathyroidism
B Aktas Yılmaz1, A Akyel, E Kan
1Department of Endocrinology and Metabolism, Gazi University School of Medicine, Ankara, Turkey. baktasyilmaz@yahoo.com.
Journal of Endocrinological Investigation
|May 14, 2013
Summary
Asymptomatic primary hyperparathyroidism (PHPT) alters cardiac structure and diastolic function, with higher left ventricular mass index and myocardial performance index observed in patients. Elevated serum calcium and parathyroid hormone levels correlate with these cardiovascular changes.
Area of Science:
- Cardiology
- Endocrinology
- Medical Research
Background:
- Cardiovascular (CV) changes in asymptomatic primary hyperparathyroidism (PHPT) are not well-documented.
- Limited data exists on cardiac structure and function in patients with asymptomatic PHPT.
Purpose of the Study:
- To compare cardiac structure and diastolic function in patients with asymptomatic PHPT and controls.
- To investigate the relationship between serum calcium/parathyroid hormone levels and cardiac parameters in PHPT.
Main Methods:
- Tissue Doppler echocardiography was used to evaluate 38 patients with asymptomatic PHPT and 31 matched controls.
- Cardiac structure (LVMI) and diastolic function (MPI) were assessed.
- Correlations between cardiac parameters and serum calcium/PTH levels were analyzed.
Main Results:
- Patients with asymptomatic PHPT showed significantly higher left ventricular mass index (LVMI) and myocardial performance index (MPI) compared to controls.
- LVMI and MPI were positively correlated with serum calcium and parathyroid hormone (PTH) levels.
- No significant difference in ejection fraction (EF) was observed between groups.
Conclusions:
- Asymptomatic PHPT is associated with altered cardiac morphology and diastolic function.
- Elevated serum PTH and calcium levels may contribute to these cardiovascular changes.
- Further research is needed to explore the impact of these changes on cardiac systolic function and mortality.
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