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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Published on: March 6, 2018

Current concepts in penile cancer.

Philippe E Spiess1, Simon Horenblas, Lance C Pagliaro

  • 1Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida 33612, USA. philippe.spiess@moffitt.org

Journal of the National Comprehensive Cancer Network : JNCCN
|May 14, 2013
PubMed
Summary

Penile cancer diagnosis and management have advanced, focusing on risk factors like human papilloma virus (HPV) and evolving surgical techniques. Multimodal therapy is crucial for advanced cases.

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Area of Science:

  • Oncology
  • Urology
  • Epidemiology

Background:

  • Penile cancer is an aggressive malignancy with a poor prognosis, often due to late presentation and varied surgical approaches.
  • Understanding risk factors, including human papilloma virus (HPV) infection, is crucial for prevention and management strategies.
  • The heterogeneity of surgical care stems from the low volume of cases treated at individual centers.

Purpose of the Study:

  • To review recent advancements in the diagnosis and management of penile cancer.
  • To discuss the evolving understanding of penile cancer risk factors and their implications.
  • To highlight contemporary treatment strategies, including surgical innovations and multimodal therapy.

Main Methods:

  • Literature review of recent studies on penile cancer diagnosis and management.
  • Analysis of risk factors, including the role of human papilloma virus (HPV).
  • Evaluation of surgical techniques, such as penile-sparing and minimally invasive approaches to inguinal lymph nodes.

Main Results:

  • Significant progress has been made in understanding penile cancer's aggressive phenotype and prognosis.
  • The association with human papilloma virus (HPV) has led to discussions on vaccination strategies.
  • Penile-sparing and minimally invasive inguinal lymph node surgery represent key advancements.
  • Multimodal therapy, including neoadjuvant chemotherapy and consolidative surgery, is effective for advanced nodal metastases.

Conclusions:

  • Penile cancer management has evolved with improved diagnostic and surgical approaches.
  • HPV vaccination is a debated but relevant socioepidemiologic consideration.
  • A multimodal approach is essential for managing bulky or locally advanced penile cancer with nodal involvement.