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No detection of simian virus 40 in malignant mesothelioma in Korea

Minseob Eom1, Jamshid Abdul-Ghafar, Sun-Mi Park

  • 1Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Korean Journal of Pathology
|May 14, 2013
PubMed
Abstract

Insights

Simian virus 40 (SV40) was not detected in Korean malignant mesothelioma (MM) tissues. This study found no association between SV40 and MM development in the Korean population.

Area of Science:

  • Oncology
  • Virology
  • Pathology

Background:

  • Simian virus 40 (SV40), a polyomavirus, has been linked to malignant mesothelioma (MM) as a cofactor with asbestos.
  • Previous reports on the SV40-MM correlation are inconsistent.
  • SV40 was initially identified as a contaminant in human polio vaccines.

Purpose of the Study:

  • To investigate the presence of SV40 in malignant mesothelioma (MM) tissue samples from Korea.
  • To detect SV40 protein and DNA in Korean MM cases.

Main Methods:

  • Analyzed 62 paraffin-embedded MM tissue blocks from the Korean Malignant Mesothelioma Surveillance System.
  • Utilized immunohistochemistry to detect SV40 protein.
  • Employed real-time polymerase chain reaction (PCR) to quantify SV40 DNA and transcripts.

Main Results:

  • Immunohistochemistry revealed no detectable SV40 protein in any of the 62 MM tissue samples.
  • SV40 DNA was analyzed in 36 cases, with quantitative PCR showing no significant increase compared to negative controls.
  • No SV40 transcripts were detected in the analyzed Korean MM samples.

Conclusions:

  • The findings indicate that Simian virus 40 (SV40) is not associated with the development of malignant mesothelioma (MM) in Korea.
  • This study provides evidence against a role for SV40 in Korean MM pathogenesis.
Keywords:
ImmunohistochemistryMesotheliomaPolymerase chain reactionSimian virus 40

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