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Updated: May 11, 2026

Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Helicobacter pylori and Gastric Inflammation: Role of MUC1 Mucin
Erik P Lillehoj1, Wei Guang, Hua Ding
1Division of Pulmonology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Abstract:
More than half of the world's population is infected with Helicobacter pylori, which is strongly linked to the development of chronic gastric inflammation (gastritis), peptic ulcer disease, and stomach cancer. However, for unknown reasons, the vast majority of infected individuals are asymptomatic beyond histologic inflammation. This review article will summarize current knowledge on the molecular mechanisms of H. pylori colonization of the gastric mucosa, with a particular focus on the biochemistry of MUC1 mucin in the host response to bacterial infection.
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