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Related Experiment Video

Updated: May 11, 2026

LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation

LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation

Published on: May 3, 2024

A role for programmed cell death in the microbial loop.

Mónica V Orellana¹, Wyming L Pang, Pierre M Durand

¹Institute for Systems Biology, Seattle, Washington, United States of America.

|May 14, 2013

Summary

This summary is machine-generated.

Programmed cell death (PCD) in Dunaliella salina releases nutrients, fueling population growth and supporting Halobacterium salinarum. This process is vital for nutrient cycling in aquatic ecosystems.

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Published on: January 20, 2023

Area of Science:

Microbiology
Ecology
Biochemistry

Background:

The microbial loop describes nutrient recycling in aquatic ecosystems.
Programmed cell death (PCD) is known in unicellular organisms, but its ecological role is unclear.

Purpose of the Study:

To investigate the impact of PCD on population growth.
To determine PCD's role in carbon exchange between halophilic organisms.

Main Methods:

Flow cytometry
Biochemical assays
Carbon-14 radioisotope tracing
Global transcriptomic analysis

Main Results:

PCD in Dunaliella salina releases organic photosynthate, complementing nutrition for non-PCD D. salina cells and enhancing population growth in vitro.
Halobacterium salinarum re-mineralizes released carbon, providing nutrients for the chlorophyte.
H. salinarum can utilize lysed apoptotic algae as a sole carbon source.

Conclusions:

PCD in D. salina facilitates dissolved photosynthate flow between unrelated organisms.
Programmed death is crucial for population growth and nutrient exchange within the microbial loop.