Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Efferent Copy and Corollary Discharge Motor Control Behavior Associated with a Hopping Activity.

Journal of novel physiotherapies·2022
Same journal

Enhancing Anticipatory Postural Adjustments: A Novel Approach to Balance Rehabilitation.

Journal of novel physiotherapies·2016
Same journal

Acute Effects of Enhanced Eccentric and Concentric Resistance Exercise on Metabolism and Inflammation.

Journal of novel physiotherapies·2016
Same journal

Train the Brain: Novel Electroencephalography Data Indicate Links between Motor Learning and Brain Adaptations.

Journal of novel physiotherapies·2014
Same journal

Measurement of Aerobic Capacity Using Mouthpiece vs. Mask for Data Collection.

Journal of novel physiotherapies·2014
Same journal

An Informational Algorithm as the Basis for Perception-Action Control of the Instantaneous Axes of the Knee.

Journal of novel physiotherapies·2014

Related Experiment Video

Updated: May 11, 2026

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

Overtraining, Exercise, and Adrenal Insufficiency.

Ka Brooks1, Jg Carter

  • 1Department of Kinesiology, Texas A&M University, USA.

Journal of Novel Physiotherapies
|May 14, 2013
PubMed
Summary

Chronic overtraining can lead to adrenal insufficiency and severe fatigue in athletes. This condition, known as Overtraining Syndrome (OS), results from excessive training stress overwhelming the body's recovery capacity.

Area of Science:

  • Sports Medicine
  • Endocrinology
  • Exercise Physiology

Background:

  • Moderate aerobic exercise benefits health, but excessive training can cause chronic stress.
  • Overtraining Syndrome (OS) is linked to adrenal gland dysfunction and insufficiency.
  • The adrenal glands are crucial for stress response and hormone production.

Purpose of the Study:

  • To review the relationship between overtraining, chronic fatigue, and adrenal insufficiency.
  • To examine the overlap between these conditions.
  • To analyze research on adrenal axis dysfunction in overtrained athletes.

Main Methods:

  • Literature review of studies on overtraining, stress, and adrenal function.
  • Analysis of the physiological impact of chronic overtraining on the endocrine system.
Keywords:
Adrenal axisChronic fatigueEndurance athletesOvertraining syndromeStress

More Related Videos

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Related Experiment Videos

Last Updated: May 11, 2026

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

  • Examination of the definition and symptoms of Overtraining Syndrome.

    • Main Results:

    • Chronic overtraining, especially when combined with other stressors, can lead to Overtraining Syndrome (OS).
    • OS is characterized by chronic fatigue, burnout, and staleness due to an imbalance in training and recovery.
    • Severe, prolonged overtraining can cause adrenal depletion and potentially Addison-Type overtraining syndrome, compromising hormone levels and athletic performance.

    Conclusions:

    • Overtraining Syndrome presents a significant risk to athletes' health, particularly impacting adrenal function.
    • Adrenal insufficiency is a key concern in chronic overtraining, leading to severe fatigue and performance decline.
    • Further research is needed to fully understand the adrenal axis dysfunction in stressed and overtrained athletes.