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Related Experiment Video

Updated: May 11, 2026

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

[Study on andrographolide solid dispersion vectored by hydroxyapatite].

Shao-Ying Hu¹, Zhen-Hai Zhang, Xiao-Bin Jia

¹Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. hsy872805820@163.com

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|May 15, 2013

Summary

This summary is machine-generated.

Hydroxyapatite effectively enhances the dissolution and stability of the water-insoluble drug andrographolide. This solid dispersion formulation shows improved drug release and sustained properties.

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Area of Science:

Pharmaceutical Sciences
Materials Science

Context:

Andrographolide is a water-insoluble drug with limited bioavailability.
Improving the dissolution rate of poorly soluble drugs is a significant challenge in pharmaceutical development.

Purpose:

To develop and characterize an andrographolide-hydroxyapatite solid dispersion.
To enhance the dissolution and stability of andrographolide.

Summary:

Andrographolide and hydroxyapatite were prepared into a solid dispersion using the solvent evaporation method.
Characterization confirmed the amorphous state of andrographolide within the hydroxyapatite matrix (1:8 ratio).
The solid dispersion exhibited significantly improved in vitro dissolution (93% at 45 min) and stability over three months.

Impact:

This formulation offers a promising approach to improve the therapeutic efficacy of andrographolide.
The use of hydroxyapatite as a vector demonstrates its potential for enhancing poorly soluble drug delivery.