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Updated: May 11, 2026

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
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Sucralose.

Omar A A AlDeeb1, Hoda Mahgoub, Nagwa H Foda

  • 1Department of Pharmaceutical Chemistry, Hail University, Hail, Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology
|May 15, 2013
PubMed
Summary
This summary is machine-generated.

Sucralose, a zero-calorie artificial sweetener, offers stability for cooking and baking. This review details its synthesis, physical properties, and comprehensive ADME profile for potential use in diabetes and obesity management.

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Area of Science:

  • Food Science
  • Analytical Chemistry
  • Pharmacology

Background:

  • Sucralose is a chlorinated sucrose derivative, approximately 600 times sweeter than sucrose.
  • It is a nonnutritive, zero-calorie sweetener approved by the FDA in 1998.
  • Its heat stability makes it suitable for baked and fried foods, unlike other artificial sweeteners.

Purpose of the Study:

  • To provide a comprehensive profile of sucralose.
  • To review its physical, analytical, and ADME (absorption, distribution, metabolism, and elimination) profiles.
  • To present methods of sucralose synthesis and its nutritional aspects.

Main Methods:

  • Recording and interpretation of spectral data (X-ray powder diffraction, DSC, FT-IR, NMR, ESI-MS).
  • Review of compendial, spectroscopic, and chromatographic analytical techniques.
  • Compilation of ADME data, pharmacokinetic, and pharmacological effects.

Main Results:

  • Detailed spectral assignments and interpretation provided for various analytical techniques.
  • Comprehensive ADME profile including absorption, distribution, metabolism, and elimination data.
  • Review of chemical and microbiological synthesis schemes for sucralose.

Conclusions:

  • Sucralose possesses a well-defined physical and analytical profile.
  • Its ADME characteristics and pharmacological effects are thoroughly documented.
  • The review consolidates information on sucralose synthesis and its application in managing diabetes and obesity.