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Related Experiment Video

Updated: May 11, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

Updated guidelines on outpatient anticoagulation.

Patricia Wigle¹, Bradley Hein, Hanna E Bloomfield

¹Division of Pharmacy Practice and Administrative Sciences, University of Cincinnati James L. Winkle College of Pharmacy, Cincinnati, OH 45267, USA. patricia.wigle@uc.edu

American Family Physician

|May 15, 2013

Summary

This summary is machine-generated.

The American College of Chest Physicians updated guidelines recommend warfarin for venous thromboembolism and stroke prevention in atrial fibrillation. New anticoagulants like dabigatran and apixaban are also discussed for atrial fibrillation stroke prevention.

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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Area of Science:

Cardiology
Pharmacology
Internal Medicine

Background:

The American College of Chest Physicians (ACCP) provides guidelines for anticoagulant use in primary care.
Warfarin, a vitamin K antagonist, is a key anticoagulant for venous thromboembolism (VTE) and stroke prevention in atrial fibrillation (AF).

Purpose of the Study:

To summarize ACCP recommendations for anticoagulant therapy.
To highlight updates in anticoagulant options and their indications since 2008.

Main Methods:

Review of the 9th edition of ACCP guidelines (2012).
Focus on warfarin initiation, management, and perioperative considerations.
Inclusion of newer anticoagulants approved by the U.S. Food and Drug Administration (FDA).

Main Results:

Warfarin requires initial bridging with heparin or fondaparinux for VTE treatment.
International Normalized Ratio (INR) monitoring is crucial for warfarin efficacy and safety.
Newer oral anticoagulants (NOACs) like dabigatran and apixaban are approved for stroke prevention in nonvalvular AF.
Rivaroxaban is indicated for DVT/PE treatment and prevention, and stroke prevention in nonvalvular AF.

Conclusions:

ACCP guidelines offer comprehensive recommendations for anticoagulant therapy.
Warfarin management involves specific protocols for initiation, monitoring, and surgical interruption.
Emerging anticoagulants provide alternative options for specific patient populations and indications.