Related Experiment Video
Updated: May 11, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Progress in molecular-based management of differentiated thyroid cancer
Mingzhao Xing1, Bryan R Haugen, Martin Schlumberger
1Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mxing1@jhmi.edu
Recent advances in thyroid cancer research have yielded new diagnostic molecular markers and targeted treatments. These innovations improve risk stratification and management for thyroid nodules and advanced thyroid cancer.
Area of Science:
- Oncology
- Molecular Medicine
- Translational Research
Background:
- Thyroid cancer diagnosis and management have seen significant advancements in recent years.
- Molecular markers are increasingly crucial for understanding thyroid nodule behavior.
Purpose of the Study:
- To review recent developments in clinical translational research for thyroid cancer.
- To highlight the impact of molecular markers and targeted therapies on patient care.
Main Methods:
- Review of recent scientific literature on thyroid cancer molecular markers and targeted treatments.
- Analysis of clinical trial data for novel therapeutic strategies.
Main Results:
- Diagnostic molecular markers (e.g., BRAF V600E mutations, gene expression classifiers) have improved thyroid nodule diagnosis and risk stratification.
- BRAF mutation analysis aids in tailoring treatment for thyroid cancer patients.
- Molecular-targeted therapies show promise for refractory and inoperable thyroid cancers.
Conclusions:
- Molecular advancements are revolutionizing thyroid nodule diagnosis and thyroid cancer management.
- Novel targeted treatments are expected to become standard care for specific thyroid cancer patient groups.
More Related Videos
03:55Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
06:08Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...