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Updated: May 11, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
Herpes simplex encephalitis with occipital localization in an infant: a different route of entry in the brain system?
Elisabetta Venturini1, Elena Chiappini, Claudio Fonda
1Department of Sciences for Woman and Child's Health, University of Florence, Anna Meyer, Children's University Hospital, Florence, Italy.
Abstract:
Herpes simplex encephalitis classically involves the periventricular white matter in infants and the mesial temporal lobes, inferior frontal lobes, and insula in older children and adults. However, the increasing use of polymerase chain reaction to detect viral DNA in the cerebrospinal fluid has allowed the expansion of the spectrum of radiologic findings possibly associated with herpes simplex encephalitis. This study presents a rare case of a previously healthy infant with herpes simplex encephalitis with occipital involvement and permanent visual impairment. Possible pathogenic mechanisms are discussed.
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