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Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy

Jing Tan1, Qiang Yu

  • 1Genome Institute of Singapore, Agency for Science, Technology and Research, Biopolis, Singapore. tanj@gis.a-star.edu.sg

Chinese Journal of Cancer
|May 15, 2013
PubMed

Insights

Drug resistance limits the success of PI3K-mTOR inhibitors in cancer treatment. Understanding PI3K-dependent and -independent resistance mechanisms is crucial for developing strategies to overcome them.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • The phosphatidylinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) signaling pathway is frequently deregulated in human cancers.
  • This pathway is a key driver of tumorigenesis, making it a target for anticancer drug development.

Purpose of the Study:

  • To summarize current knowledge of resistance mechanisms to PI3K-mTOR inhibitors.
  • To discuss strategies for overcoming drug resistance for improved clinical application.

Main Methods:

  • Literature review of PI3K-mTOR inhibitor resistance mechanisms.
  • Analysis of PI3K-dependent and -independent resistance pathways.

Main Results:

  • Small-molecule inhibitors targeting the PI3K-mTOR pathway show clinical efficacy.
  • Drug resistance, driven by various mechanisms, can limit therapeutic success.

Conclusions:

  • Understanding resistance mechanisms is essential for effective cancer therapy.
  • Developing strategies to overcome resistance is critical for the clinical application of PI3K-mTOR inhibitors.

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