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Updated: May 11, 2026

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
Published on: April 6, 2017
Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity
Zhiqiang Zhou1, Xiaoyi Wei2, Huizheng Fu3
1Pharmaceutical Department of Nanchang University, Nanchang 330006, PR China; Jiangxi Provincial Institute for Drug and Food Control, Nanchang 330029, PR China.
Abstract:
Two new triterpenoids, 2α,3α,19α,23-tetrahydroxyurs-12,20(30)-dien-28-oic acid (1) and 2α,3α,19α-trihydroxyurs-12-en-28-oic acid-28-O-β-D-xylopyranosyl (1→2)-β-D-glucopyranoside (2), and a new acylated flavone glycoside, luteolin 3'-O-(6″-E-caffeoyl)-β-D-glucopyranoside (3), together with three known compounds (4-6), were isolated from the leaves of Callicarpa nudiflora Hook. Their structures were elucidated on the basis of spectroscopic data and chemical methods. Anti-platelet aggregation activities of these compounds were evaluated in vitro. Compounds 1 and 2 showed inhibitory effects on ADP-induced platelet aggregation with EC50 values of 9.48 μM and 25.31 μM, respectively.
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