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Postictal ventricular tachycardia after electroconvulsive therapy treatment associated with a lithium-duloxetine
Boeker Heinz1, Perniola Lorenzo, Risch Markus
1Department of Psychiatry, Psychotherapy and Psychosomatics, Zurich University, Hospital for Psychiatry, Lenggstrasse 31, Postfach 1931, CH-8032 Zürich, Switzerland. heinz.boeker@bli.uzh.ch
Insights
This case study highlights cardiovascular risks during electroconvulsive therapy (ECT) for patients on lithium and antidepressants. Adjusting medication and muscle relaxants allowed safe continuation of ECT, suggesting further research is needed.
Area of Science:
- Neuroscience
- Psychiatry
- Clinical Pharmacology
Background:
- Recurrent affective disorders often require long-term treatment with mood stabilizers like lithium and antidepressants.
- Electroconvulsive therapy (ECT) is an effective treatment for severe mood disorders but carries potential cardiovascular risks.
- Concurrent use of lithium and certain antidepressants may increase these risks during ECT.
Abstract:
This report addresses the dilemma of continuing lithium prophylaxis and antidepressant therapy in view of cardiovascular adverse effects under electroconvulsive therapy (ECT) in patients with a long history of recurrent affective disorders. A severely depressed 48-year-old woman who had been treated with lithium for 18 years developed a ventricular tachycardia during ECT. Possible interaction with succinylcholine was taken into account, and rocuronium was used as an alternative muscle relaxant. Electroconvulsive therapy was continued without adverse effects after reduction of lithium and withdrawal from duloxetine. Systemic studies on cardiac adverse effects of serotonin and norepinephrine reuptake inhibitors and serotonin and norepinephrine reuptake inhibitor-lithium combinations during ECT are needed.
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