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Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

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Related Experiment Video

Updated: May 11, 2026

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
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Proteomics in aortic aneurysm--what have we learnt so far?

Nada Abdulkareem1, Philipp Skroblin, Marjan Jahangiri

  • 1Department of Cardiothoracic Surgery, St George's Hospital University of London, London, UK.

Proteomics. Clinical Applications
|May 15, 2013
PubMed
Summary

This study performed proteomics analysis of the aortic extracellular matrix (ECM) to understand aortic remodeling. Findings offer insights into aortic aneurysm pathogenesis and potential new biomarkers.

Keywords:
Aortic aneurysmBiomarkersClinical complications

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Last Updated: May 11, 2026

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06:08

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Published on: March 8, 2019

Area of Science:

  • Vascular Biology
  • Proteomics
  • Biochemistry

Background:

  • Aortic aneurysm is a silent disease with severe complications like rupture and dissection.
  • The aortic extracellular matrix (ECM) provides structural support and regulates cell signaling.
  • Previous proteomics studies homogenized vascular tissue, losing spatial information and facing dynamic range limitations.

Purpose of the Study:

  • To conduct an in-depth proteomics analysis of the aortic ECM.
  • To identify molecular processes driving aortic remodeling and structural failure.
  • To uncover novel biomarkers for aortic diseases.

Main Methods:

  • Unbiased proteomics discovery approach targeting the ECM.
  • Analysis of extracellular matrix sub-proteome in healthy and diseased aortas.
  • Quantitative proteomics without relying on homogenized tissue samples.

Main Results:

  • Detailed proteomics profile of the aortic ECM.
  • Identification of key ECM components involved in aortic remodeling.
  • Insights into cell-matrix interactions during disease progression.

Conclusions:

  • Targeting the ECM proteome offers a novel approach to study aortic diseases.
  • Understanding ECM composition is crucial for deciphering pathogenic mechanisms in aortic aneurysm.
  • This research may lead to the discovery of new diagnostic and therapeutic targets.