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Updated: May 11, 2026
Isolation of Human Mesenchymal Stem Cells and their Cultivation on the Porous Bone Matrix
Published on: February 9, 2015
Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells
Akhilesh K Gaharwar1, Silvia M Mihaila, Archana Swami
1Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard medical School, Cambridge, MA 02115, USA.
Abstract:
Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.
