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Can statins improve outcomes after isolated cardiac valve surgery? A systematic literature review

Jacob Chacko1, Leanne Harling, Hutan Ashrafian

  • 1Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

Clinical Cardiology
|May 15, 2013
PubMed

Insights

Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) show no clear benefit in isolated valve surgery outcomes. More research is needed to determine if statins alone improve patient results after valve replacement.

Area of Science:

  • Cardiovascular Surgery
  • Pharmacology
  • Clinical Outcomes

Background:

  • Statins are known to improve outcomes in coronary artery surgery.
  • The role of statins in isolated valve surgery (IVS) is not well-established.
  • Pleiotropic effects of statins may benefit patients undergoing IVS.

Purpose of the Study:

  • To investigate the role of statin therapy in bioprosthetic valve replacement.
  • To determine if statins confer a postoperative benefit in isolated valve surgery.

Main Methods:

  • Systematic review of the literature.
  • Inclusion of nine observational studies (7 retrospective, 2 prospective).
  • Analysis of data from 18,154 patients.

Main Results:

  • Nine studies involving 18,154 patients were analyzed.
  • The studies focused on statin therapy in bioprosthetic valve replacement.
  • Current evidence is insufficient to support routine statin use in IVS.

Conclusions:

  • Insufficient evidence exists to recommend routine statin therapy for isolated valve surgery.
  • Statin therapy may be considered if hypercholesterolemia or coronary artery disease is present.
  • Prospective studies are required to define optimal statin therapy for postoperative benefit.
Abstract

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