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CD163 binding to haptoglobin-hemoglobin complexes involves a dual-point electrostatic receptor-ligand pairing.

Marianne Jensby Nielsen1, Christian Brix Folsted Andersen, Søren Kragh Moestrup

  • 1Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

The Journal of Biological Chemistry
|May 15, 2013
PubMed
Summary

The haptoglobin (Hp)-hemoglobin (Hb) complex binds to the CD163 receptor. Acidic amino acids in CD163 domains 2 and 3, and basic residues in Hp, are crucial for this high-affinity binding.

Keywords:
Calcium-binding ProteinsHemoglobinLigand-binding proteinReceptor EndocytosisScavenger Receptor

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