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Related Concept Videos

Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
Disorders of the Urinary System01:20

Disorders of the Urinary System

The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
The Micturition Reflex01:26

The Micturition Reflex

Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...
Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
Diabetes Insipidus I: Introduction01:29

Diabetes Insipidus I: Introduction

Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

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Related Experiment Video

Updated: May 11, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

The other bladder syndrome: underactive bladder.

Minoru Miyazato, Naoki Yoshimura, Michael B Chancellor

    Reviews in Urology
    |May 15, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Underactive bladder (UAB) involves weak bladder contractions, leading to incomplete emptying. Management focuses on preventing complications and exploring new therapies like stem cells and gene therapy.

    Keywords:
    Detrusor overactivityDiabetic cystopathyOveractive bladderUnderactive bladder

    More Related Videos

    Real-Time Void Spot Assay
    06:39

    Real-Time Void Spot Assay

    Published on: February 10, 2023

    Related Experiment Videos

    Last Updated: May 11, 2026

    Detrusor Underactivity Model in Rats by Conus Medullaris Transection
    03:26

    Detrusor Underactivity Model in Rats by Conus Medullaris Transection

    Published on: August 28, 2020

    Real-Time Void Spot Assay
    06:39

    Real-Time Void Spot Assay

    Published on: February 10, 2023

    Area of Science:

    • Urology
    • Nephrology
    • Neurology

    Background:

    • Underactive bladder (UAB) is characterized by reduced detrusor muscle contraction strength or duration.
    • This condition leads to prolonged or incomplete bladder emptying, affecting quality of life.
    • Diabetic cystopathy is a significant complication of UAB, often developing early and asymptomatically.

    Purpose of the Study:

    • To define underactive bladder (UAB) and its clinical implications.
    • To outline diagnostic approaches for UAB.
    • To review current and emerging management strategies for UAB.

    Main Methods:

    • Diagnosis relies on careful neurologic and urodynamic examinations.
    • Management strategies include scheduled voiding, double voiding, alpha-blockers, and intermittent self-catheterization.
    • Investigational therapies include sacral nerve stimulation, stem cell therapy, and neurotrophic gene therapy.

    Main Results:

    • UAB necessitates management focused on preventing upper urinary tract damage and reducing residual urine.
    • Conservative treatments aim to improve bladder emptying and prevent overdistension.
    • Emerging therapies show promise for more effective UAB management.

    Conclusions:

    • Underactive bladder (UAB) requires timely diagnosis and management to prevent complications.
    • Current treatments are primarily conservative, with novel therapeutic avenues under investigation.
    • Pharmaceutical and biotech industries should consider UAB as a target for developing new treatments.