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A rare coexistence: drug induced hepatitis and meningitis in association with Ibuprofen

Suresh Kumar Nayudu1, Shilpa Kavuturu, Masooma Niazi

  • 1Division of Gastroenterology and Hepatology, Bronx Lebanon Hospital Center, Affiliated with Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA ; Department of Medicine, Bronx Lebanon Hospital Center, Affiliated with Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA.

Journal of Clinical Medicine Research
|May 15, 2013
PubMed

Insights

Ibuprofen (a nonsteroidal anti-inflammatory drug) can cause liver injury and meningitis. This case report details a rare instance where a patient experienced both conditions simultaneously after taking ibuprofen.

Area of Science:

  • Pharmacology
  • Hepatology
  • Neurology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are widely used for pain and inflammation.
  • Ibuprofen is a known cause of drug-induced liver injury (DILI) and drug-induced meningitis, particularly in individuals with connective tissue disorders.
  • Concurrent presentation of hepatitis and meningitis linked to ibuprofen has not been previously documented.

Observation:

  • A young woman presented with elevated liver enzymes and neurological symptoms during ibuprofen therapy.
  • Her clinical presentation and laboratory findings were consistent with ibuprofen-induced hepatitis and aseptic meningitis.
  • Liver biopsy confirmed drug-induced liver injury, and cerebrospinal fluid analysis indicated aseptic meningitis.

Findings:

  • The patient experienced simultaneous hepatitis and aseptic meningitis attributed to ibuprofen use.
  • Cessation of ibuprofen led to significant clinical and biochemical improvement.
  • This case highlights a rare, dual adverse reaction to ibuprofen.

Implications:

  • This case underscores the potential for ibuprofen to cause concurrent liver and neurological adverse events.
  • Clinicians should consider ibuprofen as a potential cause of hepatitis and meningitis, especially when symptoms occur together.
  • Further investigation into the mechanisms underlying these dual toxicities may be warranted.
Keywords:
HepatitisIbuprofenMeningitis

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