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Updated: May 11, 2026

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Published on: October 9, 2018

In utero transplantation: Disparate ramifications.

John S Pixley¹, Esmail D Zanjani

¹John S Pixley, Rheumatology/Immunology Division, Department of Medicine, VA Sierra Health Care System and the University of Nevada School of Medicine, Reno, NV 89557, United States.

World Journal of Stem Cells

|May 15, 2013

Summary

This summary is machine-generated.

In utero stem cell transplantation offers early treatment for genetic disorders by leveraging natural self-tolerance acquired during gestation. This method is crucial for understanding stem cells and developing therapies for diseases like hematolymphoid conditions and diabetes.

Keywords:

Immune ontogeny Self non-self discrimination Stem cell transplantation

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Last Updated: May 11, 2026

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Published on: October 9, 2018

Surgical Approach, Challenges, and Resolutions for Uterus Transplantation in Rats

Surgical Approach, Challenges, and Resolutions for Uterus Transplantation in Rats

Published on: April 14, 2023

Area of Science:

* Developmental Biology
* Immunology
* Regenerative Medicine

Background:

* Self-tolerance is established during gestation, a key insight from Ray Owen's research.
* In utero transplantation (IUT) has been instrumental in characterizing hematopoietic stem cells.
* Understanding self-tolerance is critical for advancing transplantation science.

Purpose of the Study:

* To review the applications of in utero stem cell transplantation (IUT).
* To highlight IUT's role in understanding self-tolerance.
* To summarize IUT's potential as a therapeutic strategy for various diseases.

Main Methods:

* Review of preclinical and clinical research on IUT.
* Analysis of studies characterizing hematopoietic stem cells via IUT.
* Examination of IUT's role in studying immune tolerance.

Main Results:

* IUT is a valuable tool for hematopoietic stem cell characterization.
* IUT aids in understanding the mechanisms of self-tolerance.
* Preclinical development shows promise for IUT in treating childhood hematolymphoid diseases.
* IUT presents potential therapeutic avenues for diabetes and other conditions.

Conclusions:

* In utero stem cell transplantation is a significant technique in both basic and applied research.
* IUT holds promise for treating genetic disorders and other diseases early in development.
* Further research and development of IUT are warranted for clinical applications.