Related Experiment Videos
Dermatomyositis associated with gallbladder carcinoma: A case report.
Qing-Feng Ni1, Guo-Qing Liu, Li-Yong Pu
1Qing-Feng Ni, Guo-Qing Liu, Li-Yong Pu, Liang-Liang Kong, Lian-Bao Kong, Department of Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, The National Institute of Living Donor Liver Transplantation, Nanjing 210029, Jiangsu Province, China.
World Journal of Hepatology
|May 15, 2013
Summary
Gallbladder carcinoma can manifest as paraneoplastic syndromes like dermatomyositis. Surgical removal of the gallbladder tumor resolved the patient's dermatomyositis, highlighting this connection.
Area of Science:
- Oncology
- Dermatology
- Medical Diagnostics
Background:
- Gallbladder carcinoma can present with various paraneoplastic syndromes.
- These syndromes, including dermatomyositis, often resolve after surgical tumor resection.
- Dermatomyositis is an inflammatory condition affecting muscles and skin.
Purpose of the Study:
- To investigate the potential link between gallbladder carcinoma and dermatomyositis.
- To highlight the importance of considering malignancy in patients presenting with unusual paraneoplastic syndromes.
- To report a case where dermatomyositis was the initial presentation of gallbladder carcinoma.
Main Methods:
- Case report of a 67-year-old female patient.
- Initial diagnosis of dermatomyositis based on clinical presentation (facial and cervical erythema).
- Diagnostic imaging including abdominal computed tomography (CT) and positron emission tomography-CT (PET-CT) to investigate suspected gallbladder carcinoma with lymph node metastasis.
- Surgical resection of the primary gallbladder tumor.
Main Results:
- The patient's initial symptoms were attributed to dermatomyositis.
- Imaging revealed gallbladder carcinoma with lymph node metastasis.
- Post-surgical resection of the gallbladder tumor led to the complete resolution of dermatomyositis symptoms.
- Histopathological confirmation of gallbladder carcinoma post-surgery.
Conclusions:
- Dermatomyositis can be an early, albeit rare, manifestation of gallbladder carcinoma.
- Surgical resection of the primary malignancy is curative for associated paraneoplastic syndromes.
- This case underscores the necessity of a thorough oncological workup for patients with paraneoplastic syndromes of unclear etiology.
Related Concept Videos
01:20Cholecystitis
Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
01:17Gallbladder
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...
01:23Cirrhosis I: Introduction
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
01:26Diseases of the Liver and Gallbladder
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
01:20Myasthenia Gravis: Overview and Treatment
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
01:19Appendicitis
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...