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Human rotavirus associated diarrhea and strain diversity in Nepal

S B Pun1, B D Pandey

  • 1Sukraraj Tropical and Infectious Diseases Hospital, Kathmandu, Nepal. drsherbdr@yahoo.com

Nepal Medical College Journal : NMCJ
|May 16, 2013
PubMed

Insights

Rotavirus is a leading cause of severe diarrhea in Nepalese children under five. Continued surveillance is crucial for understanding rotavirus strains and vaccine impact in Nepal.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Diarrheal disease is a significant cause of illness and death in Nepalese children.
  • Rotavirus is a primary pathogen responsible for severe pediatric diarrhea globally.
  • New rotavirus vaccines have demonstrated efficacy in reducing disease burden.

Purpose of the Study:

  • To systematically review existing literature on rotavirus infection in Nepal.
  • To understand the prevalence and circulating strains of rotavirus in Nepalese children.
  • To inform the potential introduction and impact of rotavirus vaccination in Nepal.

Main Methods:

  • Systematic literature search of national and international health databases.
  • Extraction and analysis of data from five selected articles published between 1978 and 2010.
  • Analysis of rotavirus prevalence and G and P genotypes from 3671 participants.

Main Results:

  • Rotavirus infection prevalence ranged from 12% to 39% among analyzed participants.
  • G1P[8] was the most common genotype (25%), followed by G12P[6] (23%) and G2P[4] (16%) between 2003-2007.
  • Rotavirus was identified as the most common cause of severe diarrhea in children under five in Nepal.

Conclusions:

  • Rotavirus is a major contributor to severe diarrhea in young children in Nepal.
  • The diversity of circulating rotavirus strains necessitates ongoing epidemiological surveillance.
  • Surveillance is essential for evaluating the effectiveness of rotavirus vaccination programs in Nepal.

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