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EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: May 11, 2026

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

Pluripotent stem cells for Parkinson's disease: progress and challenges.

Xianmin Zeng, Larry A Couture

Stem Cell Research & Therapy

|May 16, 2013

Summary

Human pluripotent stem cells offer a promising alternative for Parkinson's disease (PD) cell replacement therapy. These cells can be differentiated into dopaminergic neurons, showing potential for future clinical trials.

Area of Science:

Neuroscience
Stem Cell Biology
Regenerative Medicine

Background:

Parkinson's disease (PD) involves progressive loss of dopamine-producing neurons, leading to motor deficits.
Current PD therapies are palliative, often ineffective long-term, and can cause side effects.
Fetal cell transplantation for PD has shown some benefit but faces limitations in availability and consistency.

Purpose of the Study:

To review the potential of human pluripotent stem cells (hPSCs) for Parkinson's disease cell replacement therapy.
To assess the suitability of hPSCs for clinical application in PD treatment.
To evaluate current manufacturing processes, cell purity, and safety for clinical trials.

Main Methods:

Reviewing existing research on hPSC differentiation into dopaminergic neurons.

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Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells

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Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons

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Related Experiment Videos

Last Updated: May 11, 2026

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells

Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells

Published on: September 15, 2014

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons

Published on: July 7, 2023

Analyzing studies involving transplantation of hPSCs into PD animal models.

Evaluating manufacturing, purity, and tumorigenicity data for clinical readiness.

Main Results:

hPSCs can be differentiated into functional dopaminergic neurons in culture.
Transplanted hPSCs have shown survival, engraftment, and behavioral improvement in PD models.
Several research groups are advancing hPSC-based therapies towards clinical trials.

Conclusions:

hPSCs represent a viable and promising alternative to fetal cells for PD cell replacement therapy.
Further development is needed to optimize manufacturing, ensure cell purity, and address tumorigenicity concerns for clinical use.
hPSC-derived dopaminergic neurons hold significant potential for future Parkinson's disease treatments.