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Updated: May 11, 2026
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
Plasma-seq: a novel strategy for metastatic prostate cancer analysis
Caitlin Farris1, Jeffrey M Trimarchi1
1Department of Genetics, Development and Cell Biology, 2114 Molecular Biology, Iowa State University, Ames, IA 50011, USA.
Genome Medicine
|May 16, 2013
Summary
A new plasma-seq method rapidly and affordably sequences circulating tumor DNA, advancing personalized cancer genomics for patient prognosis monitoring.
Area of Science:
- Genomic Medicine
- Oncology
- Molecular Diagnostics
Background:
- Personalized genomics is crucial for cancer patient prognosis but requires cost-effective and rapid methods.
- Current genomic sequencing techniques can be time-consuming and expensive, limiting clinical application.
Purpose of the Study:
- To introduce plasma-seq, a novel, rapid, and low-cost method for sequencing circulating tumor DNA.
- To demonstrate the utility of plasma-seq in analyzing tumor genomes from cancer patients.
Main Methods:
- Development of plasma-seq, a technique for sequencing cell-free DNA from peripheral blood.
- Application of plasma-seq to analyze tumor genomes in a cohort of prostate cancer patients.
Main Results:
- Plasma-seq offers a faster and more economical approach to genomic analysis of circulating tumor DNA.
- The study successfully demonstrated the application of plasma-seq for examining tumor genomes in prostate cancer.
Conclusions:
- Plasma-seq significantly enhances the feasibility of using personalized genomics for cancer patient prognosis.
- This method represents a step towards making advanced genomic monitoring more accessible in clinical settings.