Related Experiment Video
Updated: May 11, 2026

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
Published on: April 11, 2019
Depression in patients with newly diagnosed epilepsy predicts lamotrigine-induced rash: a short-term observational
1Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. sppark@mail.knu.ac.kr
Abstract:
Lamotrigine (LTG) has a good efficacy and tolerability as initial monotherapy for patients with newly diagnosed epilepsy (NDE). However, the occurrence of skin rash is one of the main reasons to discontinue LTG. On the basis of a high frequency of adverse effects associated with antiepileptic drugs in depressed patients, this study investigated whether depression is a likely predictor of LTG-induced rash in patients with NDE. Eligible patients received LTG monotherapy and were observed for 12 weeks. Twenty (27%) of 74 enrolled patients had depression. Ten patients (13.5%) developed a skin rash within 5 weeks. Depression was a sole predictor of LTG-induced rash (OR=9.154, 95% CI 2.077-40.344, p=0.003).
Related Concept Videos
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: Glutamate Antagonists
Electroconvulsive Therapy
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Long-term Depression