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Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
The metabolism of lymphomas
M Nieves Calvo-Vidal1, Leandro Cerchietti
1Hematology and Oncology Division, Medicine Department, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA.
Current Opinion in Hematology
|May 16, 2013
Summary
Lymphoma cells exhibit high glucose uptake, driven by nucleotide biosynthesis and altered glycine-folate metabolism. Understanding these metabolic pathways offers new therapeutic strategies for lymphoma treatment.
Area of Science:
- Oncology
- Metabolic pathways
- Cancer metabolism
Background:
- Lymphomagenesis involves complex metabolic reprogramming.
- Tumor promoting and suppressing pathways are modulated by cellular metabolism.
- Metabolite addiction plays a role in lymphoma progression.
Purpose of the Study:
- To review recent advances in lymphoma metabolism.
- To focus on metabolic modulation of tumor-promoting/suppressing pathways.
- To examine the effect of these pathways on metabolite addiction.
Main Methods:
- Review of cellular, animal, and human studies.
- Analysis of recent findings on metabolic pathways in lymphoma.
- Focus on genetic and metabolic regulators.
Main Results:
- Lymphoma cells show high glucose uptake and glycolytic activity.
- Nucleotide biosynthesis is a key driver of glycolysis, especially under stress.
- Deregulation of glycine-folate metabolism impacts nucleotide synthesis and genome integrity.
- MYC, PI3K, and TP53 play roles in regulating reactive oxygen species, glycolysis, and glutaminolysis.
- Novel metabolic pathways have been identified, leading to new antimetabolite strategies.
Conclusions:
- Lymphoma metabolism supports cell proliferation and lymphomagenesis.
- Preclinical data elucidate metabolic pathways sustaining the malignant phenotype.
- Identified pathways may impact lymphoma diagnosis, characterization, and treatment.
