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Updated: May 11, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

DEVD-based hydrogelator minimizes cellular apoptosis induction.

An-Ming Tang¹, Wei-Juan Wang, Bin Mei

¹CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.

Scientific Reports

|May 16, 2013

Summary

This summary is machine-generated.

This study designed two peptide hydrogelators: DEVD-based hydrogelator 1, sensitive to caspase-3 (CASP3), and DEDV-based hydrogelator 2. Hydrogelator 1, forming long nanofibers, showed lower apoptosis induction than hydrogelator 2.

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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Area of Science:

Biomaterials Science
Supramolecular Chemistry
Cell Biology

Background:

Peptide-based hydrogels offer tunable properties for biomedical applications.
Enzyme-responsive materials are crucial for targeted drug delivery and tissue engineering.
Caspase-3 (CASP3) plays a key role in apoptosis.

Purpose of the Study:

To rationally design and synthesize two isomeric heptapeptide hydrogelators.
To investigate the enzyme susceptibility and self-assembly behavior of these hydrogelators.
To evaluate the impact of hydrogelator structure on cellular apoptosis.

Main Methods:

Synthesis of DEVD-based (1) and DEDV-based (2) heptapeptide hydrogelators.
Characterization of hydrogel morphology (nanofibers) and mechanical strength.
In vitro enzymatic assays for caspase-3 (CASP3) susceptibility.
Cell viability assays (MTT) and Western blot analysis to assess apoptosis.

Main Results:

Hydrogelator 1 self-assembled into long, flexuous nanofibers forming a hydrogel with higher mechanical strength.
Hydrogelator 2 self-assembled into short, rigid nanofibers.
Hydrogelator 1 was susceptible to CASP3, while hydrogelator 2 was not.
Hydrogelator 2 induced significant cell death via apoptosis, whereas hydrogelator 1 minimized apoptosis.

Conclusions:

The sequence of peptide hydrogelators dictates their self-assembly, mechanical properties, and enzyme responsiveness.
DEVD-based hydrogelator 1 offers a promising platform for applications requiring minimal apoptosis induction.
DEDV-based hydrogelator 2 demonstrates potential for applications aimed at inducing apoptosis.