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Related Concept Videos

Diversity of Antigen Receptors01:28

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3 variants are also...
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Related Experiment Video

Updated: May 11, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous &beta;2-Microglobulin
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Structural and dynamic features of HLA-B27 subtypes.

Barbara Uchanska-Ziegler1, Andreas Ziegler, Peter Schmieder

  • 1Institut für Immungenetik, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Thielallee 73, 14195 Berlin, Germany.

Current Opinion in Rheumatology
|May 16, 2013
PubMed
Summary

Investigating human leukocyte antigen B27 (HLA-B27) subtypes reveals how minor molecular differences influence ankylosing spondylitis. These variations in HLA-B27 molecules are key to understanding disease initiation.

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Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Rheumatology

Background:

  • Ankylosing spondylitis (AS) is strongly associated with human leukocyte antigen B27 (HLA-B27).
  • HLA-B27 exists as numerous subtypes, suggesting differential disease association.
  • Understanding the molecular basis of these associations is crucial for AS pathogenesis research.

Purpose of the Study:

  • To review recent research on minimally distinct HLA-B27 subtypes.
  • To investigate the biochemical and biophysical properties of these subtypes.
  • To correlate these properties with ankylosing spondylitis pathogenesis.

Main Methods:

  • Biochemical techniques
  • Biophysical techniques
  • Analysis of micropolymorphisms in HLA-B27 molecules
  • Monoclonal antibody (mAb) binding assays
  • Antigen flexibility assessment

Main Results:

  • Micropolymorphisms within the HLA-B27 peptide-binding groove significantly alter molecular properties.
  • Distinct subtype and peptide-dependent dynamics of HLA-B27 heterotrimers are implicated in disease initiation.
  • Evidence suggests these dynamics are crucial for understanding HLA-B27-associated spondyloarthropathies.

Conclusions:

  • Structurally distinct HLA-B27 subsets can be identified using specific monoclonal antibodies.
  • Assessing HLA-B27 antigen flexibility offers insights into early disease mechanisms.
  • These approaches may elucidate molecular events in the initial stages of spondyloarthropathies.