[The effect of methylation on the carnitine synthesis]

The effect of vitamin B12, its analogs and donors of methyl groups on the coupling of methylation and carnitine accumulation in rats was studied. Biological active forms of vitamin B12 (methylcobalamine, cyanocobalamine, hydroxycobalamine) are shown to stimulate the carnitine synthesis in liver. The donor of methyl groups S-methylmethionine, also has a positive effect. Factor B does not influence the carnitine level. The stimulating effect of vitamin B12 and donors in methyl groups on the carnitine synthesis seems to result from activation of methylation.