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Urine NGAL and KIM-1 in children and adolescents with hyperuricemia

Justyna Tomczak1, Anna Wasilewska, Robert Milewski

  • 1Department of Paediatrics and Nephrology, Medical University of Bialystok, ul. Waszyngtona 17, 15-274, Białystok, Poland.

Pediatric Nephrology (Berlin, Germany)
|May 16, 2013
PubMed

Insights

Pediatric hyperuricemia is linked to elevated urine neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) levels. These findings suggest potential kidney damage markers in children with high uric acid levels.

Area of Science:

  • Pediatric Nephrology
  • Biomarker Discovery
  • Uric Acid Metabolism

Background:

  • Hyperuricemia is a condition characterized by elevated uric acid levels in the blood.
  • Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) are recognized biomarkers of acute kidney injury and kidney disease.
  • The association between hyperuricemia and these urinary biomarkers in pediatric populations requires further investigation.

Purpose of the Study:

  • To investigate whether urine NGAL and KIM-1 levels are elevated in pediatric patients diagnosed with hyperuricemia.
  • To explore the correlation between serum uric acid levels and urinary NGAL and KIM-1 concentrations in adolescents.
  • To identify factors influencing NGAL and KIM-1 levels in hyperuricemic adolescents.

Main Methods:

  • A cohort of 88 children and adolescents (median age 16 years) were evaluated.
  • Participants were categorized into a hyperuricemic (HU) group (n=59) and a normouricemic reference group (n=29).
  • Urine NGAL and KIM-1 levels were measured using commercial kits and normalized to creatinine.

Main Results:

  • Urine NGAL and KIM-1 levels, including their ratios with creatinine, were significantly higher in the HU group compared to the reference group (p < 0.01).
  • Positive correlations were observed between serum uric acid and both urine NGAL/creatinine (R=0.67, p < 0.001) and urine KIM-1/creatinine ratios (R=0.36, p < 0.001).
  • Multiple regression analysis indicated that serum uric acid, systolic blood pressure, and cholesterol significantly predicted NGAL/creatinine ratios, while serum uric acid, gender, age, and systolic blood pressure predicted KIM-1/creatinine ratios.

Conclusions:

  • Adolescents with hyperuricemia, particularly males who are obese and hypertensive, exhibit increased urinary NGAL and KIM-1 levels.
  • These findings suggest that NGAL and KIM-1 may serve as valuable urinary biomarkers for detecting kidney involvement in pediatric hyperuricemia.
  • Further research is warranted to elucidate the clinical implications and potential diagnostic utility of these biomarkers in pediatric kidney health.
Abstract

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