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Updated: May 11, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
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A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

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Leukoaraiosis and carotid artery stenosis: evaluation with CT angiography

Hakan Demirtaş1, Can Özkaynak, Mehmet Sedat Durmaz

  • 1Department of Radiology, Yalvac Hospital, Isparta, Turkey.

Journal of Computer Assisted Tomography
|May 16, 2013
PubMed

Insights

Leukoaraiosis is common in older adults and significantly correlates with carotid artery stenosis severity. This suggests leukoaraiosis may indicate advanced atherosclerosis.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Radiology

Background:

  • Leukoaraiosis, a marker of cerebral small vessel disease, is prevalent in aging populations.
  • Carotid artery stenosis is a significant risk factor for stroke.
  • The relationship between leukoaraiosis and carotid artery stenosis requires further elucidation.

Purpose of the Study:

  • To investigate the association between leukoaraiosis and carotid artery stenosis.
  • To determine if the severity of leukoaraiosis correlates with the degree of carotid artery stenosis.

Main Methods:

  • Retrospective analysis of 194 patients' carotid-cerebral multislice computed tomography angiographies.
  • Evaluation of leukoaraiosis presence and severity using European Task Force criteria.
  • Assessment of carotid artery stenosis based on North American Symptomatic Carotid Endarterectomy Trial criteria.

Main Results:

  • Leukoaraiosis was observed in 52% of the study cohort.
  • Significant correlations were found between age and both leukoaraiosis and carotid artery stenosis.
  • A significant relationship exists between the presence of leukoaraiosis and carotid artery stenosis, with severity positively correlating.

Conclusions:

  • Leukoaraiosis is more frequent in elderly individuals.
  • The positive correlation between leukoaraiosis severity and carotid artery stenosis degree suggests a potential link to advanced atherosclerosis.
  • These findings highlight leukoaraiosis as a potential indicator of systemic vascular disease.
Abstract

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